LOC_ABRAMSON-Abramson Building Req ID: 82869
Employment Status: Regular – Full Time
Dr. Falk’s research laboratory at The Children’s Hospital of Philadelphia Research Institute was established in 2006 and is focused in researching the mechanisms underlying disease, and potential novel therapies, for mitochondrial respiratory chain diseases. The laboratory primarily uses human cell, C. elegans (worm), zebrafish, small animal models, and occasionally mouse models for these purposes.
We have a position open immediately for a research technician to join the group to investigate the therapeutic mechanisms of primary mitochondrial disease through whole-animal behavioral phenotyping and mitochondrial physiology studies, as well as assisting in the evaluation of the efficacy and toxicity of pharmacologic agents in both cell and animal models of primary mitochondrial respiratory chain diseases. This work involves analyses of candidate therapies and high-throughput drug screening, with both academic and pharma partners.
Prior experience is highly desirable in performing translational investigations in C. elegans (worm), zebrafish, and/or human cell culture, working with pharmacologic agents, microscopy, flow sorting, and standard molecular laboratory investigations including gene expression profiling, cell sorting analyses, gene sequencing, and western blot analyses. Experience performing high-throughput drug screening in cells and animal models is strongly preferred. Experience with mitochondrial models or physiology investigations and/or training in pharmacology is highly desirable. The successful applicant will be a team player, work independently but with regular communication with the PI and study team, have strong data analysis skills including in Excel, Prism, ImageJ, and Matlab, excellent organization skills, be a quick learner, be highly attentive to detail, have excellent communication skills, and be able to make a 2 year commitment to this research
• Bachelor’s degree required
• Minimum 18 months relevant laboratory experience required.
To learn more about this lab:
- Performs routine tests under the direction of principal investigator or supervisor
- Performs research procedures on experimental samples as directed
- Records and checks results for completeness and accuracy
- Performs calculations and maintains appropriate log and lab notebooks
- Performs tasks that require familiarity with fundamental techniques and equipment
- Assists with planning specific research protocols and procedures
- Maintains office, lab area, reagents, supplies and equipment
- Cleans and performs routine maintenance on lab equipment
- Coordinates schedules of tests & procedures
- Attends courses, seminars, and lab meetings to expand knowledge of research and laboratory techniques
- Records results, organizes data and maintains lab notebook in an organized manner
- Conducts literary searches as directed
Required Licenses, Certifications, Registrations
Required Education and Experience
Required Education: Associates Degree
Required Experience: Nine (9) months of laboratory experience
Preferred Education, Experience & Cert/Lic
Preferred Education: Bachelor’s Degree
- Eighteen (18) months of laboratory experience
- Related internship experience.
Additional Technical Requirements
All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.
Children’s Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children’s Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products.
Children’s Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.
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