Location: LOC_ABRAMSON-Abramson Building
Req ID: 128851
Employment Status: Regular – Full Time
Dr. Ruffner is a pediatric allergist whose goal is to improve to care of patients with food allergy syndromes by understanding how the immune system’s interaction with food antigens and the mucosal surfaces are altered in patients with non-IgE mediated food allergies. The Ruffner laboratory studies the genetic and immunologic mechanism that underlie non-IgE mediated food allergies such as eosinophilic esophagitis (EoE) and food-protein induced enterocolitis syndrome (FPIES). The mechanism of non-IgE mediated food allergies are relatively poorly understood compared to food allergen anaphylaxis, which is mediated by IgE. The mission of our research is to improve treatment for patients with these allergies by improving the understanding of the immunologic and genetic causes of these allergic disorders.
The postdoctoral fellow (postdoc) will have a terminal degree PhD, MD, DVM, etc. and will conduct translational pediatric allergy, mucosal immunology, and epigenetics research under the direction/guidance of Dr.Melanie Ruffner at the Children’s Hospital of Philadelphia (CHOP) and University of Pennsylvania (UPenn).
The successful candidate will be dedicated and motivated, have creative thinking and be motivated to drive their research in new directions. Several possible project opportunities exist under this project umbrella for the interested candidate. These projects would build on the lab’s existing studies in a manner mindful of the fellow’s career vison. The postdoc experience will serve to extend, refine and enhance skills necessary for professional and career development, and will enable the individual to broaden their scientific background by acquiring new research skills. Our lab uses a variety of methods including air-liquid interface and organoid models of epithelial cells, flow cytometry and molecular biology assays, and analysis of multi-omics datasets such as ChIP-seq, RNA-seq, microarray and genome wide association studies (GWAS) that are generated within our lab, affiliated laboratories or from the public domain.
The preferred applicant will have a strong background working in mucosal immunology or primary epithelial cell biology using three-dimensional tissue culture models of primary cells. Experience with flow cytometry and immunoassays including ELISA or immunofluorescence are strongly preferred.
- Conduct independent scholarly research and develop new methods and protocols
- Participate in project planning, recording and evaluation of data
- Acquire technical, lab management and grant writing skills
- Participate in seminars, lectures, poster sessions and presentation at national meetings
- Supervise junior lab members
- Assist with other research projects
Required Licenses, Certifications, Registrations
Required Education and Experience
- A terminal degree PhD, MD, DVM, etc.
- According to the CMS (Centers for Medicaid and Medicare Services) a copy of diploma or transcript is required as proof of academic achievement for all non-laboratory personnel performing non-waived POC testing
Additional Technical Requirements
All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.
Children’s Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at Children’s Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products.
Children’s Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.
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