Principal Scientist 2, In Vitro

Company Name: Charles River Laboratories

Location: Worcester, MA, US - 01608

Job Duration: 2021-06-11 to 2021-07-11


For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.



Job Summary

We are seeking an experienced Principal Scientist 2, In Vitro for our Discovery site located in Worcester, MA

We are seeking a highly motivated, skilled scientist to work within the In Vitro ADME team to perform and oversee enzymatic and cell-based In Vitro assays.  The group performs in vitro assays and uses instrumentation (including automated liquid handling and LC/MS/MS) to characterize the ADME properties of drug candidate compounds to meet the discovery needs of our clients.  The main responsibilities of this position will include interacting with clients and directing studies.  This position may also supervise a small team of assay scientists.   Additional responsibilities include developing new assay capabilities, and maintaining and optimizing processes to ensure efficiency and data quality.  This individual will collaborate closely with colleagues within the group and also with other departments within the site.  


Successful candidates in this position will:

  • Possess strong interpersonal skills with strong scientific curiosity, initiative and resourcefulness
  • Possess exceptional organizational and planning skills enabling management of multiple, concurrent tasks & priorities
  • Prior direct experience with biochemical and cell-based assays, highly preferable in the in vitro ADME area (metabolism, protein binding, permeability)
  • Careful attention to detail and the accurate, organized and timely documentation of study data and report generation
  • Team orientation, highly collaborative and results-oriented focus
  • Self-driven and enthusiastic with the ability to thrive in a dynamic environment



    The following are minimum requirements related to the Principal Scientist 2, In Vitro position.

    • Education:  Bachelor’s Degree (B.S./B.A) or equivalent in a scientific related discipline. Master’s degree (M.S./M.A.) or Ph.D. preferred.
    • Experience:  Minimum of 8 years previous directly related laboratory experience in a pharmaceutical or contract laboratory environment. An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above.
    • Other:  Exceptional analytical and problem solving capabilities. Full understanding of regulatory requirements of study types assigned, as well as Testing Facility SOPs and Good Laboratory Practices (GLPs), as appropriate. Excellent written and verbal communication skills in a team environment. Able to prioritize work and meet deadlines under minimal direction. Proficiency in the use of standard software including Microsoft® Excel, Word, PowerPoint, etc. and with standard laboratory calculations. Proficiency in the use of analytical instrumentation software with the ability to troubleshoot for routine and non-routine work. Experience with LIMS systems is desired.


    About Discovery
    Discovery from Charles River is industry-proven in the successful development of novel therapies, with over 320 patents and 74 preclinical drug candidates delivered to our sponsors in the past 17 years. Backed by more than 650 scientists, our comprehensive, integrated portfolio employs the latest technology and platforms to provide chemistry, biology, and pharmacology services that support clients from the earliest stages of hit identification all the way through to IND. Our client-focused, collaborative approach creates true partnerships that anticipate challenges, overcome obstacles, and move us forward together on the journey of getting new drugs to market.

    About Charles River
    Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

    With over 11,000 employees within 70 facilities in 18 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges.  Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2016, revenue increased by 23.3% to $1.68 billion from $1.36 billion in 2015.

    At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of ~70% of the drugs approved by the FDA in 2016.

    For more information, please visit

    Equal Employment Opportunity
    Charles River Laboratories, Inc. is an Equal Opportunity Employer M/F/Disabled/Vet